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Gasdermin
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | + | The 3D structure of GSDM A3 shows the monomer of the pore formed by the N-terminal of the molecule. Each subunit contributes 4 long β strands to the transmembrane region of the pore. The pore is formed by 27-fold symmetry<ref>PMID:29695864</ref>. | |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 10:12, 11 July 2022
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References
- ↑ Xia S, Hollingsworth LR 4th, Wu H. Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3). pii: cshperspect.a036400. doi: , 10.1101/cshperspect.a036400. PMID:31451512 doi:http://dx.doi.org/10.1101/cshperspect.a036400
- ↑ Orning P, Lien E, Fitzgerald KA. Gasdermins and their role in immunity and inflammation. J Exp Med. 2019 Nov 4;216(11):2453-2465. doi: 10.1084/jem.20190545. Epub 2019 Sep, 23. PMID:31548300 doi:http://dx.doi.org/10.1084/jem.20190545
- ↑ Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021 May;20(5):384-405. doi: 10.1038/s41573-021-00154-z., Epub 2021 Mar 10. PMID:33692549 doi:http://dx.doi.org/10.1038/s41573-021-00154-z
- ↑ Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 May;557(7703):62-67. doi: 10.1038/s41586-018-0058-6. Epub 2018 Apr, 25. PMID:29695864 doi:http://dx.doi.org/10.1038/s41586-018-0058-6
