1fnf
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(New page: 200px<br /> <applet load="1fnf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fnf, resolution 2.0Å" /> '''FRAGMENT OF HUMAN FI...)
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Revision as of 14:48, 12 November 2007
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FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Contents |
Overview
We have determined the 2.0 A crystal structure of a fragment of human, fibronectin encompassing the seventh through the RGD-containing tenth type, III repeats (FN7-10). The structure reveals an extended rod-like molecule, with a long axis of approximately 140 A and highly variable relationships, between adjacent domains. An unusually small rotation between domains 9, and 10 creates a distinctive binding site, in which the RGD loop from, domain 10 and the "synergy" region from domain 9 are on the same face of, FN7-10 and thus easily accessible to a single integrin molecule. The, cell-binding RGD loop is well-ordered in this structure and extends, approximately 10 A away from the FN7-10 core.
Disease
Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[135600]
About this Structure
1FNF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Leahy DJ, Aukhil I, Erickson HP, Cell. 1996 Jan 12;84(1):155-64. PMID:8548820
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