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1fnl
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(New page: 200px<br /> <applet load="1fnl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fnl, resolution 1.8Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 14:49, 12 November 2007
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII
Contents |
Overview
Fc receptors play a major role in immune defenses against pathogens and in, inflammatory processes. The crystal structure of a human immunoglobulin, receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The, overall fold consists of two immunoglobulin-like domains with an acute, interdomain hinge angle of approximately 50 degrees. Trp-113, wedged, between the N-terminal D1 and the C-terminal D2 domains, appears to, further restrict the hinge angle. The putative Fc binding region of the, receptor carries a net positive charge complementary to the, negative-charged receptor binding regions on Fc. A 1:1 binding, stoichiometry between the receptor and Fc was measured by both the, equilibrium and nonequilibrium size-exclusion chromatography. Two separate, parallel dimers are observed in the crystal lattice, offering intriguing, models for receptor aggregation.
Disease
Known diseases associated with this structure: Lupus erythematosus, systemic, susceptibility OMIM:[146740], Neutropenia, alloimmune neonatal OMIM:[146740], Viral infections, recurrent OMIM:[146740]
About this Structure
1FNL is a Single protein structure of sequence from Homo sapiens with HG as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the extracellular domain of a human Fc gamma RIII., Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD, Immunity. 2000 Sep;13(3):387-95. PMID:11021536
Page seeded by OCA on Mon Nov 12 16:55:30 2007
