1fns

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spinqualitylabelsall models 1fns, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Platelet participation in hemostasis and arterial thrombosis requires the, binding of glycoprotein (GP) Ibalpha to von Willebrand factor (vWF)., Hemodynamic forces enhance this interaction, an effect mimicked by the, substitution I546V in the vWF A1 domain. A water molecule becomes, internalized near the deleted Ile methyl group. The change in, hydrophobicity of the local environment causes positional changes, propagated over a distance of 27 A. As a consequence, a major, reorientation of a peptide plane occurs in a surface loop involved in GP, Ibalpha binding. This distinct vWF conformation shows increased platelet, adhesion and provides a structural model for the initial regulation of, thrombus formation.

Disease

Known diseases associated with this structure: von Willebrand disease OMIM:[193400]

About this Structure

1FNS is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule., Celikel R, Ruggeri ZM, Varughese KI, Nat Struct Biol. 2000 Oct;7(10):881-4. PMID:11017197

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