7e8l
From Proteopedia
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==The structure of Spodoptera litura chemosensory protein== | ==The structure of Spodoptera litura chemosensory protein== | ||
| - | <StructureSection load='7e8l' size='340' side='right'caption='[[7e8l]]' scene=''> | + | <StructureSection load='7e8l' size='340' side='right'caption='[[7e8l]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E8L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e8l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E8L FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e8l OCA], [https://pdbe.org/7e8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e8l RCSB], [https://www.ebi.ac.uk/pdbsum/7e8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e8l ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e8l OCA], [https://pdbe.org/7e8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e8l RCSB], [https://www.ebi.ac.uk/pdbsum/7e8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e8l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Spodoptera litura F. is a generalist herbivore and one of the most important economic pests feeding on about 300 host plants in many Asian countries. Specific insect behaviors can be stimulated after recognizing chemicals in the external environment through conserved chemosensory proteins (CSPs) in chemoreceptive organs, which are critical components of the olfactory systems. To explore its structural basis for ligand-recognizing capability, we solved the 2.3 A crystal structure of the apoprotein of S. litura CSP8 (SlCSP8). The SlCSP8 protein displays a conserved spherical shape with a negatively charged surface. Our binding assays showed that SlCSP8 bound several candidate ligands with differential affinities, with rhodojaponin III being the most tightly bound ligand. Our crystallographic and biochemical studies provide important insight into the molecular recognition mechanism of the sensory protein SlCSP8 and the CSP family in general, and they suggest that CSP8 is critical for insects to identify rhodojaponin III, which may aid in the CSP-based rational drug design in the future. | ||
| + | |||
| + | The Crystal Structure of the Spodoptera litura Chemosensory Protein CSP8.,Jia Q, Zeng H, Zhang J, Gao S, Xiao N, Tang J, Dong X, Xie W Insects. 2021 Jul 1;12(7). pii: insects12070602. doi: 10.3390/insects12070602. PMID:34357261<ref>PMID:34357261</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7e8l" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Gao S]] | + | [[Category: Gao, S]] |
| - | [[Category: Jia Q]] | + | [[Category: Jia, Q]] |
| - | [[Category: Tang J]] | + | [[Category: Tang, J]] |
| - | [[Category: Xiao N]] | + | [[Category: Xiao, N]] |
| - | [[Category: Xie W]] | + | [[Category: Xie, W]] |
| - | [[Category: Zeng H]] | + | [[Category: Zeng, H]] |
| - | [[Category: Zhang J]] | + | [[Category: Zhang, J]] |
| + | [[Category: Alpha-helical protein]] | ||
| + | [[Category: Chemosensory protein]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 05:22, 13 July 2022
The structure of Spodoptera litura chemosensory protein
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