This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3u0s
From Proteopedia
| Line 1: | Line 1: | ||
==Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6== | ==Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6== | ||
| - | <StructureSection load='3u0s' size='340' side='right' caption='[[3u0s]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='3u0s' size='340' side='right'caption='[[3u0s]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3u0s]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3u0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0S FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e1a|1e1a]], [[3i1c|3i1c]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e1a|1e1a]], [[3i1c|3i1c]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DFPASE ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DFPASE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6622 Common European squid])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0s OCA], [https://pdbe.org/3u0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0s RCSB], [https://www.ebi.ac.uk/pdbsum/3u0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0s ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 27: | Line 27: | ||
[[Category: Common european squid]] | [[Category: Common european squid]] | ||
[[Category: Diisopropyl-fluorophosphatase]] | [[Category: Diisopropyl-fluorophosphatase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Bale, J B]] | [[Category: Bale, J B]] | ||
[[Category: Shen, B W]] | [[Category: Shen, B W]] | ||
Revision as of 05:52, 13 July 2022
Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6
| |||||||||||
Categories: Common european squid | Diisopropyl-fluorophosphatase | Large Structures | Bale, J B | Shen, B W | Stoddard, B L | Active site redesign | Beta-propeller | Computationally-directed design | Computer-aided design | Crowdsourcing | De novo protein | Diels-alder | Enzyme design | Foldit | Helix-loop-helix | Hydrolase | Loop remodel | Multiplayer online gaming | Protein engineering | Substrate specificity
