3u0s
From Proteopedia
(Difference between revisions)
Line 1: | Line 1: | ||
==Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6== | ==Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6== | ||
- | <StructureSection load='3u0s' size='340' side='right' caption='[[3u0s]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='3u0s' size='340' side='right'caption='[[3u0s]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3u0s]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3u0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0S FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e1a|1e1a]], [[3i1c|3i1c]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e1a|1e1a]], [[3i1c|3i1c]]</div></td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DFPASE ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DFPASE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6622 Common European squid])</td></tr> |
- | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0s OCA], [https://pdbe.org/3u0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0s RCSB], [https://www.ebi.ac.uk/pdbsum/3u0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0s ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Line 27: | Line 27: | ||
[[Category: Common european squid]] | [[Category: Common european squid]] | ||
[[Category: Diisopropyl-fluorophosphatase]] | [[Category: Diisopropyl-fluorophosphatase]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Bale, J B]] | [[Category: Bale, J B]] | ||
[[Category: Shen, B W]] | [[Category: Shen, B W]] |
Revision as of 05:52, 13 July 2022
Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6
|
Categories: Common european squid | Diisopropyl-fluorophosphatase | Large Structures | Bale, J B | Shen, B W | Stoddard, B L | Active site redesign | Beta-propeller | Computationally-directed design | Computer-aided design | Crowdsourcing | De novo protein | Diels-alder | Enzyme design | Foldit | Helix-loop-helix | Hydrolase | Loop remodel | Multiplayer online gaming | Protein engineering | Substrate specificity