3u0y
From Proteopedia
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==Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP== | ==Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP== | ||
| - | <StructureSection load='3u0y' size='340' side='right' caption='[[3u0y]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='3u0y' size='340' side='right'caption='[[3u0y]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3u0y]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3u0y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0Y FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ioh|3ioh]], [[3ioi|3ioi]], [[3ioj|3ioj]], [[3u0x|3u0x]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ioh|3ioh]], [[3ioi|3ioi]], [[3ioj|3ioj]], [[3u0x|3u0x]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0y OCA], [https://pdbe.org/3u0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0y RCSB], [https://www.ebi.ac.uk/pdbsum/3u0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0y ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. |
| + | |||
| + | ==See Also== | ||
| + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Jorgensen, R]] | [[Category: Jorgensen, R]] | ||
[[Category: Palcic, M M]] | [[Category: Palcic, M M]] | ||
Revision as of 05:53, 13 July 2022
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP
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Categories: Human | Large Structures | Jorgensen, R | Palcic, M M | Semi closed conformation | Abo | Blood group antigen | Glycoprotein | Glycosyltransferase | H-antigen acceptor | Manganese | Membrane | Metal-binding | Rossmann fold | Transferase | Transferase gtb | Transferase-transferase inhibitor complex | Udp-gal
