3u1y
From Proteopedia
(Difference between revisions)
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==Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections== | ==Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections== | ||
| - | <StructureSection load='3u1y' size='340' side='right' caption='[[3u1y]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3u1y' size='340' side='right'caption='[[3u1y]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3u1y]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3u1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U1Y FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03I:(2R)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)-4-{4-[3-(MORPHOLIN-4-YL)PROPOXY]BIPHENYL-4-YL}BUTANAMIDE'>03I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03I:(2R)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)-4-{4-[3-(MORPHOLIN-4-YL)PROPOXY]BIPHENYL-4-YL}BUTANAMIDE'>03I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u1y OCA], [https://pdbe.org/3u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u1y RCSB], [https://www.ebi.ac.uk/pdbsum/3u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u1y ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Abramite, J]] | [[Category: Abramite, J]] | ||
[[Category: Brown, M]] | [[Category: Brown, M]] | ||
Revision as of 05:54, 13 July 2022
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
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