3u7n

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==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==
==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==
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<StructureSection load='3u7n' size='340' side='right' caption='[[3u7n]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3u7n' size='340' side='right'caption='[[3u7n]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u7n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UHF:N-((2R,4S)-2-BUTYL-5-METHYL-4-(3-(5-METHYLPYRIDIN-2-YL)UREIDO)-3-OXOHEXYL)-N-HYDROXYFORMAMIDE'>UHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UHF:N-((2R,4S)-2-BUTYL-5-METHYL-4-(3-(5-METHYLPYRIDIN-2-YL)UREIDO)-3-OXOHEXYL)-N-HYDROXYFORMAMIDE'>UHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u7k|3u7k]], [[3u7l|3u7l]], [[3u7m|3u7m]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u7k|3u7k]], [[3u7l|3u7l]], [[3u7m|3u7m]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sacol1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sacol1100 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7n OCA], [http://pdbe.org/3u7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7n RCSB], [http://www.ebi.ac.uk/pdbsum/3u7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7n OCA], [https://pdbe.org/3u7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7n RCSB], [https://www.ebi.ac.uk/pdbsum/3u7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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[[https://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Peptide deformylase]]
[[Category: Peptide deformylase]]
[[Category: Staac]]
[[Category: Staac]]

Revision as of 06:01, 13 July 2022

Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

PDB ID 3u7n

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