User:Sabrina K.K. Komatsu/Sandbox 1

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===The TOPRIM domain===
===The TOPRIM domain===
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The TOPRIM domain contains a DxD motif, where metal ion binding occurs due to two aspartates at positions 541 and 543, which coordinates a single magnesium 2 plus ion quelation,and a glutamate residue, that donates a proton to the sugar hydroxyl of the DNA during cleavage and abstracting the proton from the 3ʹ-OH during re-ligation. The TOPRIM domain also contributes to DNA binding, due to conserved residues, namely the EGDS and PLRGK motifs, which interact with the G-segment. Furthermore, the TOPRIM employs a distinct insertion, called insertion 2, composed of a short helix followed by a long loop, known for accommodation of DNA <ref name="lara"/>.
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The TOPRIM domain contains a DxD motif, where metal ion binding occurs due to two aspartates at positions 541 and 543, which coordinates a single magnesium 2 plus ion quelation,and a glutamate residue, that donates a proton to the sugar hydroxyl of the DNA during cleavage and abstracting the proton from the 3ʹ-OH during re-ligation. The TOPRIM domain also contributes to DNA binding, due to conserved residues, namely the EGDS and PLRGK motifs, which interact with the G-segment. Furthermore, the TOPRIM employs a distinct insertion, called insertion 2, composed of a short helix followed by a long loop, known for accommodation of DNA <ref name="lara"/>.[[Image:WHD.jpg|300px|right|thumb|Positions of DNA gate domains in Topoisomesase IIα (human) (IIA)]]
===THE Winged Helix domain===
===THE Winged Helix domain===

Revision as of 17:54, 16 July 2022

DNA Topoisomerase II

DNA topoisomerase II alpha

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Sabrina K.K. Komatsu

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