1hq6

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[[Image:1hq6.jpg|left|200px]]
[[Image:1hq6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1hq6 |SIZE=350|CAPTION= <scene name='initialview01'>1hq6</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1hq6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_decarboxylase Histidine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.22 4.1.1.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HDCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1591 Lactobacillus sp.])
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-->
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|DOMAIN=
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{{STRUCTURE_1hq6| PDB=1hq6 | SCENE= }}
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|RELATEDENTRY=[[1pya|1PYA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq6 OCA], [http://www.ebi.ac.uk/pdbsum/1hq6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hq6 RCSB]</span>
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}}
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'''STRUCTURE OF PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE AT PH 8'''
'''STRUCTURE OF PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE AT PH 8'''
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[[Category: Schelp, E.]]
[[Category: Schelp, E.]]
[[Category: Worley, S.]]
[[Category: Worley, S.]]
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[[Category: carboxy-lyase]]
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[[Category: Carboxy-lyase]]
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[[Category: helix disorder]]
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[[Category: Helix disorder]]
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[[Category: less active form]]
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[[Category: Less active form]]
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[[Category: ph regulation]]
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[[Category: Ph regulation]]
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[[Category: pyruvoyl]]
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[[Category: Pyruvoyl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:06:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:08:58 2008''
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Revision as of 16:06, 2 May 2008

Image:1hq6.jpg

Template:STRUCTURE 1hq6

STRUCTURE OF PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE AT PH 8


Overview

Histidine decarboxylase (HDC) from Lactobacillus 30a produces histamine that is essential to counter waste acids, and to optimize cell growth. The HDC trimer is active at low pH and inactive at neutral to alkaline pH. We have solved the X-ray structure of HDC at pH 8 and revealed the novel mechanism of pH regulation. At high pH helix B is unwound, destroying the substrate binding pocket. At acid pH the helix is stabilized, partly through protonation of Asp198 and Asp53 on either side of the molecular interface, acting as a proton trap. In contrast to hemoglobin regulation, pH has a large effect on the tertiary structure of HDC monomers and relatively little or no effect on quaternary structure.

About this Structure

1HQ6 is a Protein complex structure of sequences from Lactobacillus sp.. Full crystallographic information is available from OCA.

Reference

pH-induced structural changes regulate histidine decarboxylase activity in Lactobacillus 30a., Schelp E, Worley S, Monzingo AF, Ernst S, Robertus JD, J Mol Biol. 2001 Mar 2;306(4):727-32. PMID:11243783 Page seeded by OCA on Fri May 2 19:06:47 2008

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