3uxo

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==Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme==
==Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme==
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<StructureSection load='3uxo' size='340' side='right' caption='[[3uxo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3uxo' size='340' side='right'caption='[[3uxo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UXO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXO FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uxn|3uxn]], [[3uxp|3uxp]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uxn|3uxn]], [[3uxp|3uxp]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxo OCA], [http://pdbe.org/3uxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uxo RCSB], [http://www.ebi.ac.uk/pdbsum/3uxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxo OCA], [https://pdbe.org/3uxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxo RCSB], [https://www.ebi.ac.uk/pdbsum/3uxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
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[[https://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3uxo" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3uxo" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[DNA polymerase|DNA polymerase]]
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Buffalo rat]]
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[[Category: Large Structures]]
[[Category: Gridley, C L]]
[[Category: Gridley, C L]]
[[Category: Jaeger, J]]
[[Category: Jaeger, J]]

Revision as of 08:15, 20 July 2022

Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme

PDB ID 3uxo

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