Stringent starvation protein
From Proteopedia
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== Function == | == Function == | ||
| - | '''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. | + | '''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism, acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. |
In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. '''Stringent starvation protein B''' (SspB) binds to residues in the tag of tmRNA proteins marking them for degradation <ref>PMID:11535833</ref>. | In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. '''Stringent starvation protein B''' (SspB) binds to residues in the tag of tmRNA proteins marking them for degradation <ref>PMID:11535833</ref>. | ||
Revision as of 09:01, 24 July 2022
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References
- ↑ Wang F, Shi J, He D, Tong B, Zhang C, Wen A, Zhang Y, Feng Y, Lin W. Structural basis for transcription inhibition by E. coli SspA. Nucleic Acids Res. 2020 Sep 25;48(17):9931-9942. doi: 10.1093/nar/gkaa672. PMID:32785630 doi:http://dx.doi.org/10.1093/nar/gkaa672
- ↑ Flynn JM, Levchenko I, Seidel M, Wickner SH, Sauer RT, Baker TA. Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10584-9. doi:, 10.1073/pnas.191375298. Epub 2001 Sep 4. PMID:11535833 doi:http://dx.doi.org/10.1073/pnas.191375298
- ↑ Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA. Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev. 2017 Aug 1;31(15):1549-1560. doi: 10.1101/gad.303701.117. Epub 2017, Sep 1. PMID:28864445 doi:http://dx.doi.org/10.1101/gad.303701.117
