1hr0

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[[Image:1hr0.jpg|left|200px]]
[[Image:1hr0.jpg|left|200px]]
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{{Structure
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|PDB= 1hr0 |SIZE=350|CAPTION= <scene name='initialview01'>1hr0</scene>, resolution 3.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1hr0", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1hr0| PDB=1hr0 | SCENE= }}
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|RELATEDENTRY=[[1qd7|1QD7]], [[1fjf|1FJF]], [[1fjg|1FJG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hr0 OCA], [http://www.ebi.ac.uk/pdbsum/1hr0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hr0 RCSB]</span>
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'''CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT'''
'''CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT'''
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[[Category: Wimberly, B T.]]
[[Category: Wimberly, B T.]]
[[Category: 30]]
[[Category: 30]]
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[[Category: if1]]
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[[Category: If1]]
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[[Category: initiation factor]]
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[[Category: Initiation factor]]
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[[Category: ribosomal subunit]]
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[[Category: Ribosomal subunit]]
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[[Category: ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:08:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:18 2008''
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Revision as of 16:08, 2 May 2008

Image:1hr0.jpg

Template:STRUCTURE 1hr0

CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT


Overview

Initiation of translation at the correct position on messenger RNA is essential for accurate protein synthesis. In prokaryotes, this process requires three initiation factors: IF1, IF2, and IF3. Here we report the crystal structure of a complex of IF1 and the 30S ribosomal subunit. Binding of IF1 occludes the ribosomal A site and flips out the functionally important bases A1492 and A1493 from helix 44 of 16S RNA, burying them in pockets in IF1. The binding of IF1 causes long-range changes in the conformation of H44 and leads to movement of the domains of 30S with respect to each other. The structure explains how localized changes at the ribosomal A site lead to global alterations in the conformation of the 30S subunit.

About this Structure

1HR0 is a Protein complex structure of sequences from Escherichia coli and Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an initiation factor bound to the 30S ribosomal subunit., Carter AP, Clemons WM Jr, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V, Science. 2001 Jan 19;291(5503):498-501. PMID:11228145 Page seeded by OCA on Fri May 2 19:08:46 2008

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