1hrk

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[[Image:1hrk.gif|left|200px]]
[[Image:1hrk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hrk |SIZE=350|CAPTION= <scene name='initialview01'>1hrk</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1hrk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1hrk| PDB=1hrk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrk OCA], [http://www.ebi.ac.uk/pdbsum/1hrk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hrk RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE'''
'''CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE'''
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[[Category: Wang, B C.]]
[[Category: Wang, B C.]]
[[Category: Wu, C K.]]
[[Category: Wu, C K.]]
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[[Category: fe2s2 cluster]]
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[[Category: Fe2s2 cluster]]
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[[Category: ferrochelatase]]
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[[Category: Ferrochelatase]]
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[[Category: heme biosynthesis]]
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[[Category: Heme biosynthesis]]
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[[Category: mature length]]
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[[Category: Mature length]]
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[[Category: proteolytically processed mitochondrial inner membrane protein]]
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[[Category: Proteolytically processed mitochondrial inner membrane protein]]
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[[Category: protoheme ferro-lyase]]
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[[Category: Protoheme ferro-lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:09:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:30 2008''
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Revision as of 16:09, 2 May 2008

Image:1hrk.gif

Template:STRUCTURE 1hrk

CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE


Overview

Human ferrochelatase (E.C. 4.99.1.1) is a homodimeric (86 kDa) mitochondrial membrane-associated enzyme that catalyzes the insertion of ferrous iron into protoporphyrin to form heme. We have determined the 2.0 A structure from the single wavelength iron anomalous scattering signal. The enzyme contains two NO-sensitive and uniquely coordinated [2Fe-2S] clusters. Its membrane association is mediated in part by a 12-residue hydrophobic lip that also forms the entrance to the active site pocket. The positioning of highly conserved residues in the active site in conjunction with previous biochemical studies support a catalytic model that may have significance in explaining the enzymatic defects that lead to the human inherited disease erythropoietic protoporphyria.

About this Structure

1HRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis., Wu CK, Dailey HA, Rose JP, Burden A, Sellers VM, Wang BC, Nat Struct Biol. 2001 Feb;8(2):156-60. PMID:11175906 Page seeded by OCA on Fri May 2 19:09:48 2008

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