1hrz

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[[Image:1hrz.gif|left|200px]]
[[Image:1hrz.gif|left|200px]]
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{{Structure
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|PDB= 1hrz |SIZE=350|CAPTION= <scene name='initialview01'>1hrz</scene>
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The line below this paragraph, containing "STRUCTURE_1hrz", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1hrz| PDB=1hrz | SCENE= }}
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|RELATEDENTRY=[[1hry|1HRY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrz OCA], [http://www.ebi.ac.uk/pdbsum/1hrz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hrz RCSB]</span>
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'''THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTI-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR'''
'''THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTI-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR'''
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[[Category: Huth, J R.]]
[[Category: Huth, J R.]]
[[Category: Werner, M H.]]
[[Category: Werner, M H.]]
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[[Category: dna binding protein/dna]]
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[[Category: Dna binding protein/dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:10:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:40 2008''
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Revision as of 16:10, 2 May 2008

Image:1hrz.gif

Template:STRUCTURE 1hrz

THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTI-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR


Overview

The solution structure of the specific complex between the high mobility group (HMG) domain of SRY (hSRY-HMG), the protein encoded by the human testis-determining gene, and its DNA target site in the promoter of the mullerian inhibitory substance gene has been determined by multidimensional NMR spectroscopy. hSRY-HMG has a twisted L shape that presents a concave surface (made up of three helices and the N- and C-terminal strands) to the DNA for sequence-specific recognition. Binding of hSRY-HMG to its specific target site occurs exclusively in the minor groove and induces a large conformational change in the DNA. The DNA in the complex has an overall 70 degrees-80 degrees bend and is helically unwound relative to classical A- and B-DNA. The structure of the complex reveals the origin of sequence-specific binding within the HMG-1/HMG-2 family and provides a framework for understanding the effects of point mutations that cause 46X,Y sex reversal at the atomic level.

About this Structure

1HRZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex., Werner MH, Huth JR, Gronenborn AM, Clore GM, Cell. 1995 Jun 2;81(5):705-14. PMID:7774012 Page seeded by OCA on Fri May 2 19:10:29 2008

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