This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8csw
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Local refinement of protein 4.2 in Class 2 of erythrocyte ankyrin-1 complex== | ==Local refinement of protein 4.2 in Class 2 of erythrocyte ankyrin-1 complex== | ||
| - | <StructureSection load='8csw' size='340' side='right'caption='[[8csw]]' scene=''> | + | <StructureSection load='8csw' size='340' side='right'caption='[[8csw]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CSW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8csw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CSW FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csw OCA], [https://pdbe.org/8csw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csw RCSB], [https://www.ebi.ac.uk/pdbsum/8csw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csw ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csw OCA], [https://pdbe.org/8csw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csw RCSB], [https://www.ebi.ac.uk/pdbsum/8csw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/EPB42_HUMAN EPB42_HUMAN]] Hereditary spherocytosis. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/EPB42_HUMAN EPB42_HUMAN]] Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhesus glycoproteins remains unknown. Here we present structures of ankyrin-1 complexes purified from human erythrocytes. We reveal the architecture of a core complex of ankyrin-1, the Rhesus proteins RhAG and RhCE, the band 3 anion exchanger, protein 4.2, glycophorin A and glycophorin B. The distinct T-shaped conformation of membrane-bound ankyrin-1 facilitates recognition of RhCE and, unexpectedly, the water channel aquaporin-1. Together, our results uncover the molecular details of ankyrin-1 association with the erythrocyte membrane, and illustrate the mechanism of ankyrin-mediated membrane protein clustering. | ||
| + | |||
| + | Architecture of the human erythrocyte ankyrin-1 complex.,Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB Nat Struct Mol Biol. 2022 Jul;29(7):706-718. doi: 10.1038/s41594-022-00792-w., Epub 2022 Jul 14. PMID:35835865<ref>PMID:35835865</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8csw" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cali T]] | + | [[Category: Cali, T]] |
| - | [[Category: Clarke | + | [[Category: Clarke, O B]] |
| - | [[Category: Johnston | + | [[Category: Johnston, J D]] |
| - | [[Category: Kim K]] | + | [[Category: Kim, K]] |
| - | [[Category: Noble | + | [[Category: Noble, A J]] |
| - | [[Category: Vallese F]] | + | [[Category: Vallese, F]] |
| - | [[Category: Yen | + | [[Category: Yen, L Y]] |
| + | [[Category: Anion exchange]] | ||
| + | [[Category: Erythrocyte]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein-structural protein complex]] | ||
Revision as of 18:21, 27 July 2022
Local refinement of protein 4.2 in Class 2 of erythrocyte ankyrin-1 complex
| |||||||||||
