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3vba
From Proteopedia
(Difference between revisions)
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==Crystal structure of methanogen 3-isopropylmalate isomerase small subunit== | ==Crystal structure of methanogen 3-isopropylmalate isomerase small subunit== | ||
| - | <StructureSection load='3vba' size='340' side='right' caption='[[3vba]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3vba' size='340' side='right'caption='[[3vba]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3vba]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3vba]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VBA FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">leuD, MJ1277 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">leuD, MJ1277 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vba OCA], [https://pdbe.org/3vba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vba RCSB], [https://www.ebi.ac.uk/pdbsum/3vba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vba ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/LEUD_METJA LEUD_METJA]] Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.<ref>PMID:17449626</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Metja]] | [[Category: Metja]] | ||
[[Category: Hwang, K Y]] | [[Category: Hwang, K Y]] | ||
Revision as of 18:36, 27 July 2022
Crystal structure of methanogen 3-isopropylmalate isomerase small subunit
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Categories: Large Structures | Metja | Hwang, K Y | Lee, E H | Cytosol | Leud | Lyase
