1hsq

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[[Image:1hsq.jpg|left|200px]]
[[Image:1hsq.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1hsq |SIZE=350|CAPTION= <scene name='initialview01'>1hsq</scene>
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The line below this paragraph, containing "STRUCTURE_1hsq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1hsq| PDB=1hsq | SCENE= }}
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|RELATEDENTRY=[[2hsp|2HSP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsq OCA], [http://www.ebi.ac.uk/pdbsum/1hsq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hsq RCSB]</span>
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'''SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA'''
'''SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA'''
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[[Category: Kohda, D.]]
[[Category: Kohda, D.]]
[[Category: Odaka, M.]]
[[Category: Odaka, M.]]
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[[Category: phosphoric diester hydrolase]]
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[[Category: Phosphoric diester hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:11:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:58 2008''
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Revision as of 16:11, 2 May 2008

Image:1hsq.jpg

Template:STRUCTURE 1hsq

SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA


Overview

SH3 (Src homology 3) domains are found in many signaling proteins and appear to function as binding modules for cytoplasmic target proteins. The solution structure of the SH3 domain of human phospholipase C-gamma (PLC-gamma) was determined by two-dimensional 1H NMR analysis. This SH3 domain is composed of eight antiparallel beta strands consisting of two successive "Greek key" motifs, which form a barrel-like structure. The conserved aliphatic and aromatic residues form a hydrophobic pocket on the molecular surface, and the conserved carboxylic residues are localized to the periphery. The hydrophobic pocket may serve as a binding site for target proteins. Analysis of the slowly exchanging amide protons by NMR measurements indicates that despite containing a high content of beta structure, the SH3 domain of PLC-gamma is flexible.

About this Structure

1HSQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the SH3 domain of phospholipase C-gamma., Kohda D, Hatanaka H, Odaka M, Mandiyan V, Ullrich A, Schlessinger J, Inagaki F, Cell. 1993 Mar 26;72(6):953-60. PMID:7681365 Page seeded by OCA on Fri May 2 19:11:34 2008

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