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3vt4

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==Crystal structures of rat VDR-LBD with R270L mutation==
==Crystal structures of rat VDR-LBD with R270L mutation==
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<StructureSection load='3vt4' size='340' side='right' caption='[[3vt4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3vt4' size='340' side='right'caption='[[3vt4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VT4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vt4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VT4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5YI:(1R,2Z,3R,5E,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>5YI</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YI:(1R,2Z,3R,5E,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>5YI</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zlc|2zlc]], [[3vt3|3vt3]], [[3vt5|3vt5]], [[3vt6|3vt6]], [[3vt7|3vt7]], [[3vt8|3vt8]], [[3vt9|3vt9]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zlc|2zlc]], [[3vt3|3vt3]], [[3vt5|3vt5]], [[3vt6|3vt6]], [[3vt7|3vt7]], [[3vt8|3vt8]], [[3vt9|3vt9]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt4 OCA], [http://pdbe.org/3vt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3vt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt4 OCA], [https://pdbe.org/3vt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vt4 RCSB], [https://www.ebi.ac.uk/pdbsum/3vt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
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[[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Buffalo rat]]
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[[Category: Large Structures]]
[[Category: Ikura, T]]
[[Category: Ikura, T]]
[[Category: Ito, N]]
[[Category: Ito, N]]

Revision as of 19:02, 27 July 2022

Crystal structures of rat VDR-LBD with R270L mutation

PDB ID 3vt4

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