SARM1

(Difference between revisions)

Revision as of 08:28, 28 July 2022

↑ Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. SARM1 is a metabolic sensor activated by an increased NMN/NAD(+) ratio to trigger axon degeneration. Neuron. 2021 Mar 1. pii: S0896-6273(21)00083-0. doi:, 10.1016/j.neuron.2021.02.009. PMID:33657413 doi:http://dx.doi.org/10.1016/j.neuron.2021.02.009
↑ Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J. SARM1 activation triggers axon degeneration locally via NAD(+) destruction. Science. 2015 Apr 24;348(6233):453-7. doi: 10.1126/science.1258366. Epub 2015 Apr, 23. PMID:25908823 doi:http://dx.doi.org/10.1126/science.1258366

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 <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
 == Function ==
-'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme whose activation triggers axon destruction.  SARM1 is a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>.
+'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme whose activation triggers axon destruction.  SARM1 is a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>.  SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis<ref>PMID:25908823</ref>.
 == Disease ==