Guanylate cyclase
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Guanylate cyclase'''. (GC) catalyse the conversion of GTP to cGMP ...) |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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== Relevance == | == Relevance == | ||
| - | A GC activator - Cinaciguat - is investigated as add-on to therapy of patients suffering from acute heart failure syndrome<ref>PMID:22713287</ref>. | + | A GC activator - Cinaciguat - is investigated as add-on to therapy of patients suffering from acute heart failure syndrome<ref>PMID:22713287</ref>, <ref>PMID:21606405</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 07:36, 2 August 2022
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References
- ↑ Potter LR. Guanylyl cyclase structure, function and regulation. Cell Signal. 2011 Dec;23(12):1921-6. doi: 10.1016/j.cellsig.2011.09.001. Epub, 2011 Sep 10. PMID:21914472 doi:http://dx.doi.org/10.1016/j.cellsig.2011.09.001
- ↑ Gheorghiade M, Greene SJ, Filippatos G, Erdmann E, Ferrari R, Levy PD, Maggioni A, Nowack C, Mebazaa A. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. Eur J Heart Fail. 2012 Sep;14(9):1056-66. doi: 10.1093/eurjhf/hfs093. Epub 2012, Jun 19. PMID:22713287 doi:http://dx.doi.org/10.1093/eurjhf/hfs093
- ↑ Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation. 2011 May 24;123(20):2263-73. doi: 10.1161/CIRCULATIONAHA.110.981738. PMID:21606405 doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.110.981738
