Guanylate cyclase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='7d9t' size='340' side='right' caption='Caption for this structure' scene=''> |
== Function == | == Function == | ||
| - | '''Guanylate cyclase'''. (GC) catalyse the conversion of GTP to cGMP and pyrophosphate. cGMP is a messenger that modulates various processes like platelet aggregation, neurotransmission, sexual arousal, gut peristalsis, blood pressure and more<ref>PMID:21914472</ref>. | + | '''Guanylate cyclase'''. (GC) catalyse the conversion of GTP to cGMP and pyrophosphate. cGMP is a second messenger that modulates various processes like platelet aggregation, neurotransmission, sexual arousal, gut peristalsis, blood pressure and more<ref>PMID:21914472</ref>. |
== Disease == | == Disease == | ||
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| + | Mutations in retinal GC are involved in inherited retinopathy<ref>PMID:8944027</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:41, 2 August 2022
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References
- ↑ Potter LR. Guanylyl cyclase structure, function and regulation. Cell Signal. 2011 Dec;23(12):1921-6. doi: 10.1016/j.cellsig.2011.09.001. Epub, 2011 Sep 10. PMID:21914472 doi:http://dx.doi.org/10.1016/j.cellsig.2011.09.001
- ↑ Perrault I, Rozet JM, Calvas P, Gerber S, Camuzat A, Dollfus H, Chatelin S, Souied E, Ghazi I, Leowski C, Bonnemaison M, Le Paslier D, Frezal J, Dufier JL, Pittler S, Munnich A, Kaplan J. Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis. Nat Genet. 1996 Dec;14(4):461-4. doi: 10.1038/ng1296-461. PMID:8944027 doi:http://dx.doi.org/10.1038/ng1296-461
- ↑ Gheorghiade M, Greene SJ, Filippatos G, Erdmann E, Ferrari R, Levy PD, Maggioni A, Nowack C, Mebazaa A. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. Eur J Heart Fail. 2012 Sep;14(9):1056-66. doi: 10.1093/eurjhf/hfs093. Epub 2012, Jun 19. PMID:22713287 doi:http://dx.doi.org/10.1093/eurjhf/hfs093
- ↑ Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation. 2011 May 24;123(20):2263-73. doi: 10.1161/CIRCULATIONAHA.110.981738. PMID:21606405 doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.110.981738
