Guanylate cyclase

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<StructureSection load='7d9t' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='7d9t' size='340' side='right' caption='Human GC subunit α-1 (grey) complex with subunit β-1 (green) and the activator cinaciguat (PDB ID [[7d9t]])' scene=''>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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The 3D structure of heterodimer of human GC subunit α-1 complex with subunit β-1 and the activator cinaciguat shows the cinaciguat activator binding in the haem-binding pocket of subunit β-1 and replacing the haem. The activator makes various interactions with the β-1 subunit<ref>PMID:34535643</ref>.
</StructureSection>
</StructureSection>
== References ==
== References ==
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<references/>

Revision as of 08:00, 2 August 2022

Human GC subunit α-1 (grey) complex with subunit β-1 (green) and the activator cinaciguat (PDB ID 7d9t)

Drag the structure with the mouse to rotate

References

  1. ↑ Potter LR. Guanylyl cyclase structure, function and regulation. Cell Signal. 2011 Dec;23(12):1921-6. doi: 10.1016/j.cellsig.2011.09.001. Epub, 2011 Sep 10. PMID:21914472 doi:http://dx.doi.org/10.1016/j.cellsig.2011.09.001
  2. ↑ Perrault I, Rozet JM, Calvas P, Gerber S, Camuzat A, Dollfus H, Chatelin S, Souied E, Ghazi I, Leowski C, Bonnemaison M, Le Paslier D, Frezal J, Dufier JL, Pittler S, Munnich A, Kaplan J. Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis. Nat Genet. 1996 Dec;14(4):461-4. doi: 10.1038/ng1296-461. PMID:8944027 doi:http://dx.doi.org/10.1038/ng1296-461
  3. ↑ Gheorghiade M, Greene SJ, Filippatos G, Erdmann E, Ferrari R, Levy PD, Maggioni A, Nowack C, Mebazaa A. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. Eur J Heart Fail. 2012 Sep;14(9):1056-66. doi: 10.1093/eurjhf/hfs093. Epub 2012, Jun 19. PMID:22713287 doi:http://dx.doi.org/10.1093/eurjhf/hfs093
  4. ↑ Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation. 2011 May 24;123(20):2263-73. doi: 10.1161/CIRCULATIONAHA.110.981738. PMID:21606405 doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.110.981738
  5. ↑ Liu R, Kang Y, Chen L. Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun. 2021 Sep 17;12(1):5492. doi: 10.1038/s41467-021-25617-0. PMID:34535643 doi:http://dx.doi.org/10.1038/s41467-021-25617-0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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