1htm

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{{Structure
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The line below this paragraph, containing "STRUCTURE_1htm", creates the "Structure Box" on the page.
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{{STRUCTURE_1htm| PDB=1htm | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB]</span>
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'''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION'''
'''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION'''
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[[Category: Skehel, J J.]]
[[Category: Skehel, J J.]]
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
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[[Category: influenza virus hemagglutinin]]
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[[Category: Influenza virus hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:12:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:16 2008''
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Revision as of 16:13, 2 May 2008

Image:1htm.gif

Template:STRUCTURE 1htm

STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION


Overview

Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.

About this Structure

1HTM is a Protein complex structure of sequences from Bacteria. The following page contains interesting information on the relation of 1HTM with [Hemagglutinin]. Full crystallographic information is available from OCA.

Reference

Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525 Page seeded by OCA on Fri May 2 19:12:58 2008

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