1htv

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[[Image:1htv.gif|left|200px]]
[[Image:1htv.gif|left|200px]]
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{{Structure
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|PDB= 1htv |SIZE=350|CAPTION= <scene name='initialview01'>1htv</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1htv", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1htv| PDB=1htv | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htv OCA], [http://www.ebi.ac.uk/pdbsum/1htv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1htv RCSB]</span>
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'''CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN'''
'''CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN'''
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[[Category: Liang, D.]]
[[Category: Liang, D.]]
[[Category: Ye, J.]]
[[Category: Ye, J.]]
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[[Category: beta sheet]]
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[[Category: Beta sheet]]
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[[Category: helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:13:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:19 2008''
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Revision as of 16:13, 2 May 2008

Image:1htv.gif

Template:STRUCTURE 1htv

CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN


Overview

Destripeptide (B28-B30) insulin (DTRI) is an insulin analogue that has much weaker association ability than native insulin but keeps most of its biological activity. It can be crystallized from a solution containing zinc ions at near-neutral pH. Its crystal structure has been determined by molecular replacement and refined at 1.9 A resolution. DTRI in the crystal exists as a loose hexamer compared with 2Zn insulin. The hexamer only contains one zinc ion that coordinates to the B10 His residues of three monomers. Although residues B28-B30 are located in the monomer-monomer interface within a dimer, the removal of them can simultaneously weaken both the interactions between monomers within the dimer and the interactions between dimers. Because the B-chain C-terminus of insulin is very flexible, we take the DTRI hexamer as a transition state in the native insulin dissociation process and suggest a possible dissociation process of the insulin hexamer based on the DTRI structure.

About this Structure

1HTV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of destripeptide (B28-B30) insulin: implications for insulin dissociation., Ye J, Chang W, Liang D, Biochim Biophys Acta. 2001 May 5;1547(1):18-25. PMID:11343787 Page seeded by OCA on Fri May 2 19:13:33 2008

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