1hu9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1hu9.jpg|left|200px]]
[[Image:1hu9.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1hu9 |SIZE=350|CAPTION= <scene name='initialview01'>1hu9</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1hu9", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=4HM:4-HYDROPEROXY-2-METHOXY-PHENOL'>4HM</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1hu9| PDB=1hu9 | SCENE= }}
-
|RELATEDENTRY=[[1lnh|1LNH]], [[1byt|1BYT]], [[1yge|1YGE]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hu9 OCA], [http://www.ebi.ac.uk/pdbsum/1hu9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hu9 RCSB]</span>
+
-
}}
+
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL'''
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL'''
Line 31: Line 28:
[[Category: Skrzypczak-Jankun, E.]]
[[Category: Skrzypczak-Jankun, E.]]
[[Category: Zhou, K.]]
[[Category: Zhou, K.]]
-
[[Category: enzyme inhibitor]]
+
[[Category: Enzyme inhibitor]]
-
[[Category: fe(iii) complex]]
+
[[Category: Metalloprotein]]
-
[[Category: metalloprotein]]
+
[[Category: Oxidoreductase]]
-
[[Category: oxidoreductase]]
+
[[Category: Purple lipoxygenase]]
-
[[Category: purple lipoxygenase]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:14:15 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:29 2008''
+

Revision as of 16:14, 2 May 2008

Image:1hu9.jpg

Template:STRUCTURE 1hu9

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL


Overview

Scientific research provides documented evidence that fatty acid metabolites have profound impact on carcinogenesis. Intervention into dioxygenase pathways might therefore effect development, metastasis and progression of many types of cancers. This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase. Curcumin binds to lipoxygenase in a non-competitive manner. Trapped in that complex, it undergoes photodegradation in the X-rays, but utilizes enzyme catalytic ability to form the peroxy complex Enz-Fe-O-O-R as 4-hydroperoxy-2-methoxy-phenol, that later transforms into 2-methoxycyclohexa-2,5-diene-1,4-dione. Our observations about this radiation and time-dependent inhibition add new information to the role that curcumin might play in cancer prevention and treatment.

About this Structure

1HU9 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Structure of curcumin in complex with lipoxygenase and its significance in cancer., Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J, Int J Mol Med. 2003 Jul;12(1):17-24. PMID:12792803 Page seeded by OCA on Fri May 2 19:14:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hu9"
Personal tools