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3w5e
From Proteopedia
(Difference between revisions)
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==Crystal structure of phosphodiesterase 4B in complex with compound 31e== | ==Crystal structure of phosphodiesterase 4B in complex with compound 31e== | ||
| - | <StructureSection load='3w5e' size='340' side='right' caption='[[3w5e]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3w5e' size='340' side='right'caption='[[3w5e]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3w5e]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3w5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W5E FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NVW:N-TERT-BUTYL-2-{4-[(5,5-DIOXIDO-2-PHENYL-7,8-DIHYDRO-6H-THIOPYRANO[3,2-D]PYRIMIDIN-4-YL)AMINO]PHENYL}ACETAMIDE'>NVW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NVW:N-TERT-BUTYL-2-{4-[(5,5-DIOXIDO-2-PHENYL-7,8-DIHYDRO-6H-THIOPYRANO[3,2-D]PYRIMIDIN-4-YL)AMINO]PHENYL}ACETAMIDE'>NVW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPDE4, PDE4B ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPDE4, PDE4B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w5e OCA], [https://pdbe.org/3w5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w5e RCSB], [https://www.ebi.ac.uk/pdbsum/3w5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w5e ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3w5e" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3w5e" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | [[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hanzawa, H]] | [[Category: Hanzawa, H]] | ||
[[Category: Takahashi, M]] | [[Category: Takahashi, M]] | ||
Revision as of 05:22, 3 August 2022
Crystal structure of phosphodiesterase 4B in complex with compound 31e
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