3whw

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==MTH1 in complex with Ruthenium-based inhibitor==
==MTH1 in complex with Ruthenium-based inhibitor==
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<StructureSection load='3whw' size='340' side='right' caption='[[3whw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='3whw' size='340' side='right'caption='[[3whw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3whw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WHW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3whw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WHW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RUX:[4-AMINO-2-METHYL-6-(PYRIDIN-2-YL-KAPPAN)QUINAZOLIN-7-YL-KAPPAC~7~](CARBONYL){1-[(2,6-DIMETHOXYPHENOXY)CARBONYL]CYCLOPENTA-2,4-DIEN-1-YL}RUTHENIUM'>RUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RUX:[4-AMINO-2-METHYL-6-(PYRIDIN-2-YL-KAPPAN)QUINAZOLIN-7-YL-KAPPAC~7~](CARBONYL){1-[(2,6-DIMETHOXYPHENOXY)CARBONYL]CYCLOPENTA-2,4-DIEN-1-YL}RUTHENIUM'>RUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zr1|3zr1]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zr1|3zr1]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3whw OCA], [http://pdbe.org/3whw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3whw RCSB], [http://www.ebi.ac.uk/pdbsum/3whw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3whw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3whw OCA], [https://pdbe.org/3whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3whw RCSB], [https://www.ebi.ac.uk/pdbsum/3whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3whw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3whw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3whw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Kraeling, K]]
[[Category: Kraeling, K]]
[[Category: Meggers, E]]
[[Category: Meggers, E]]

Revision as of 05:37, 3 August 2022

MTH1 in complex with Ruthenium-based inhibitor

PDB ID 3whw

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