3nty
From Proteopedia
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| <StructureSection load='3nty' size='340' side='right'caption='[[3nty]], [[Resolution|resolution]] 1.87Å' scene=''> | <StructureSection load='3nty' size='340' side='right'caption='[[3nty]], [[Resolution|resolution]] 1.87Å' scene=''> | ||
| == Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3nty]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3nty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTY FirstGlance]. <br> | 
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5P3:5-CHLORO-4-HYDROXYBIPHENYL-3-CARBOXYLIC+ACID'>5P3</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5P3:5-CHLORO-4-HYDROXYBIPHENYL-3-CARBOXYLIC+ACID'>5P3</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nty OCA], [https://pdbe.org/3nty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nty RCSB], [https://www.ebi.ac.uk/pdbsum/3nty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nty ProSAT]</span></td></tr> | 
| </table> | </table> | ||
| == Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/AK1C1_HUMAN AK1C1_HUMAN]] Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.<ref>PMID:11013348</ref> <ref>PMID:8573067</ref>   | 
| <div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| == Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 05:27, 10 August 2022
Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid
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