3wyj

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==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789==
==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789==
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<StructureSection load='3wyj' size='340' side='right' caption='[[3wyj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3wyj' size='340' side='right'caption='[[3wyj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wyj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H78:[1-OXIDANYL-2-[3-[3-[[3-[[3-[3-(2-OXIDANYL-2,2-DIPHOSPHONO-ETHYL)PHENYL]PHENYL]SULFAMOYL]PHENYL]SULFONYLAMINO]PHENYL]PHENYL]-1-PHOSPHONO-ETHYL]PHOSPHONIC+ACID'>H78</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H78:[1-OXIDANYL-2-[3-[3-[[3-[[3-[3-(2-OXIDANYL-2,2-DIPHOSPHONO-ETHYL)PHENYL]PHENYL]SULFAMOYL]PHENYL]SULFONYLAMINO]PHENYL]PHENYL]-1-PHOSPHONO-ETHYL]PHOSPHONIC+ACID'>H78</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wyi|3wyi]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wyi|3wyi]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0174, ispU, JW0169, rth, uppS, yaeS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0174, ispU, JW0169, rth, uppS, yaeS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ditrans,polycis-undecaprenyl-diphosphate_synthase_((2E,6E)-farnesyl-_diphosphate_specific) Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ditrans,polycis-undecaprenyl-diphosphate_synthase_((2E,6E)-farnesyl-_diphosphate_specific) Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyj OCA], [http://pdbe.org/3wyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyj RCSB], [http://www.ebi.ac.uk/pdbsum/3wyj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyj OCA], [https://pdbe.org/3wyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyj RCSB], [https://www.ebi.ac.uk/pdbsum/3wyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI]] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>
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[[https://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI]] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Ecoli]]
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[[Category: Large Structures]]
[[Category: Gao, J]]
[[Category: Gao, J]]
[[Category: Guo, R T]]
[[Category: Guo, R T]]

Revision as of 05:35, 10 August 2022

Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789

PDB ID 3wyj

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