3zk6
From Proteopedia
(Difference between revisions)
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==Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).== | ==Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).== | ||
| - | <StructureSection load='3zk6' size='340' side='right' caption='[[3zk6]], [[Resolution|resolution]] 2.48Å' scene=''> | + | <StructureSection load='3zk6' size='340' side='right'caption='[[3zk6]], [[Resolution|resolution]] 2.48Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3zk6]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3zk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZK6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H1I:N-(3-(5-(1-(2-(BENZO[D]THIAZOL-2-YL)HYDRAZONO)ETHYL)FURAN-2-YL)PHENYLSULFONYL)-6-PHENYLHEXANAMIDE'>H1I</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H1I:N-(3-(5-(1-(2-(BENZO[D]THIAZOL-2-YL)HYDRAZONO)ETHYL)FURAN-2-YL)PHENYLSULFONYL)-6-PHENYLHEXANAMIDE'>H1I</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zln|3zln]], [[3zlo|3zlo]], [[3zlr|3zlr]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zln|3zln]], [[3zlo|3zlo]], [[3zlr|3zlr]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zk6 OCA], [https://pdbe.org/3zk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zk6 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[B-cell lymphoma | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Colman, P M]] | [[Category: Colman, P M]] | ||
[[Category: Czabotar, P E]] | [[Category: Czabotar, P E]] | ||
Revision as of 05:49, 10 August 2022
Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).
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