7emr
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of HasAp Capturing Cobalt Tetraphenylporphyrin== | ==Crystal Structure of HasAp Capturing Cobalt Tetraphenylporphyrin== | ||
| - | <StructureSection load='7emr' size='340' side='right'caption='[[7emr]]' scene=''> | + | <StructureSection load='7emr' size='340' side='right'caption='[[7emr]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7emr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMR FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emr OCA], [https://pdbe.org/7emr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emr RCSB], [https://www.ebi.ac.uk/pdbsum/7emr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emr ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J83:Co-5,10,15,20-Tetraphenylporphyrin'>J83</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emr OCA], [https://pdbe.org/7emr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emr RCSB], [https://www.ebi.ac.uk/pdbsum/7emr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene. | ||
| + | |||
| + | Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.,Shisaka Y, Sakakibara E, Suzuki K, Stanfield JK, Onoda H, Ueda G, Hatano M, Sugimoto H, Shoji O Chembiochem. 2022 Jul 19;23(14):e202200095. doi: 10.1002/cbic.202200095. Epub, 2022 Apr 13. PMID:35352458<ref>PMID:35352458</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7emr" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Sakakibara E]] | + | [[Category: Sakakibara, E]] |
| - | [[Category: Shisaka Y]] | + | [[Category: Shisaka, Y]] |
| - | [[Category: Shoji O]] | + | [[Category: Shoji, O]] |
| - | [[Category: Sugimoto H]] | + | [[Category: Sugimoto, H]] |
| + | [[Category: Heme acquisition protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 06:31, 18 August 2022
Crystal Structure of HasAp Capturing Cobalt Tetraphenylporphyrin
| |||||||||||
