7ems
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the HasAp L85A Mutant Capturing Iron Tetraphenylporphyrin== | ==Crystal Structure of the HasAp L85A Mutant Capturing Iron Tetraphenylporphyrin== | ||
| - | <StructureSection load='7ems' size='340' side='right'caption='[[7ems]]' scene=''> | + | <StructureSection load='7ems' size='340' side='right'caption='[[7ems]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ems]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ems FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ems OCA], [https://pdbe.org/7ems PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ems RCSB], [https://www.ebi.ac.uk/pdbsum/7ems PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ems ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ems FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ems OCA], [https://pdbe.org/7ems PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ems RCSB], [https://www.ebi.ac.uk/pdbsum/7ems PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ems ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene. | ||
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| + | Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.,Shisaka Y, Sakakibara E, Suzuki K, Stanfield JK, Onoda H, Ueda G, Hatano M, Sugimoto H, Shoji O Chembiochem. 2022 Jul 19;23(14):e202200095. doi: 10.1002/cbic.202200095. Epub, 2022 Apr 13. PMID:35352458<ref>PMID:35352458</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ems" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Shisaka Y]] | + | [[Category: Shisaka, Y]] |
| - | [[Category: Shoji O]] | + | [[Category: Shoji, O]] |
| - | [[Category: Sugimoto H]] | + | [[Category: Sugimoto, H]] |
| + | [[Category: Heme acquisition protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 06:31, 18 August 2022
Crystal Structure of the HasAp L85A Mutant Capturing Iron Tetraphenylporphyrin
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