1hyj
From Proteopedia
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'''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN''' | '''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN''' | ||
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[[Category: Kutateladze, T.]] | [[Category: Kutateladze, T.]] | ||
[[Category: Overduin, M.]] | [[Category: Overduin, M.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:21:48 2008'' | |
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Revision as of 16:21, 2 May 2008
SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN
Overview
The recruitment of trafficking and signaling proteins to membranes containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediated by FYVE domains. Here, the solution structure of the FYVE domain of the early endosome antigen 1 protein (EEA1) in the free state was compared with the structures of the domain complexed with PtdIns(3)P and mixed micelles. The multistep binding mechanism involved nonspecific insertion of a hydrophobic loop into the lipid bilayer, positioning and activating the binding pocket. Ligation of PtdIns(3)P then induced a global structural change, drawing the protein termini over the bound phosphoinositide by extension of a hinge. Specific recognition of the 3-phosphate was determined indirectly and directly by two clusters of conserved arginines.
About this Structure
1HYJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:11230696 Page seeded by OCA on Fri May 2 19:21:48 2008
