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7xt3
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Hepatitis virus A 2C protein 128-335 aa== | ==Crystal Structure of Hepatitis virus A 2C protein 128-335 aa== | ||
| - | <StructureSection load='7xt3' size='340' side='right'caption='[[7xt3]]' scene=''> | + | <StructureSection load='7xt3' size='340' side='right'caption='[[7xt3]], [[Resolution|resolution]] 2.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XT3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7xt3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XT3 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xt3 OCA], [https://pdbe.org/7xt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xt3 RCSB], [https://www.ebi.ac.uk/pdbsum/7xt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xt3 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5grb|5grb]], [[5gq1|5gq1]], [[5z3q|5z3q]]</div></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xt3 OCA], [https://pdbe.org/7xt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xt3 RCSB], [https://www.ebi.ac.uk/pdbsum/7xt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xt3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/G4W9T5_9PICO G4W9T5_9PICO]] Acts as a primer for viral RNA replication and remains covalently bound to viral genomic RNA. VPg is uridylylated prior to priming replication into VPg-pUpU. The VPg-pUpU is then used as primer on the genomic RNA poly(A) by the RNA-dependent RNA polymerase to replicate the viral genome.[ARBA:ARBA00002133] Affects membrane integrity and causes an increase in membrane permeability.[ARBA:ARBA00004017] Plays a role in the assembly of the 12 pentamers into an icosahedral structure. Has not been detected in mature virions, supposedly owing to its small size.[ARBA:ARBA00002016] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[ARBA:ARBA00003097] VP0 precursor is a component of the immature procapsids.[ARBA:ARBA00003724] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chen P]] | + | [[Category: Chen, P]] |
| - | [[Category: Cui S]] | + | [[Category: Cui, S]] |
| - | [[Category: Li Z]] | + | [[Category: Li, Z]] |
| - | [[Category: Wang M]] | + | [[Category: Wang, M]] |
| - | [[Category: Wojdyla | + | [[Category: Wojdyla, J A]] |
| + | [[Category: Nonstructural protein 2c]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 06:46, 18 August 2022
Crystal Structure of Hepatitis virus A 2C protein 128-335 aa
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