7xt3

<StructureSection load='7xt3' size='340' side='right'caption='[[7xt3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[7xt3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XT3 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xt3 OCA], [https://pdbe.org/7xt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xt3 RCSB], [https://www.ebi.ac.uk/pdbsum/7xt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xt3 ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/G4W9T5_9PICO G4W9T5_9PICO]] Acts as a primer for viral RNA replication and remains covalently bound to viral genomic RNA. VPg is uridylylated prior to priming replication into VPg-pUpU. The VPg-pUpU is then used as primer on the genomic RNA poly(A) by the RNA-dependent RNA polymerase to replicate the viral genome.[ARBA:ARBA00002133] Affects membrane integrity and causes an increase in membrane permeability.[ARBA:ARBA00004017] Plays a role in the assembly of the 12 pentamers into an icosahedral structure. Has not been detected in mature virions, supposedly owing to its small size.[ARBA:ARBA00002016] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[ARBA:ARBA00003097] VP0 precursor is a component of the immature procapsids.[ARBA:ARBA00003724]

[[Category: Chen, P]]

[[Category: Cui, S]]

[[Category: Li, Z]]

[[Category: Wang, M]]

[[Category: Wojdyla, J A]]

[[Category: Viral protein]]