3zp3

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Current revision (07:07, 18 August 2022) (edit) (undo)
 
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==INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTc==
==INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTc==
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<StructureSection load='3zp3' size='340' side='right' caption='[[3zp3]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='3zp3' size='340' side='right'caption='[[3zp3]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zp3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZP3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zp0|3zp0]], [[3zp1|3zp1]], [[3zp2|3zp2]], [[3zp6|3zp6]], [[3zpa|3zpa]], [[3zpb|3zpb]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zp0|3zp0]], [[3zp1|3zp1]], [[3zp2|3zp2]], [[3zp6|3zp6]], [[3zpa|3zpa]], [[3zpb|3zpb]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp3 OCA], [http://pdbe.org/3zp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zp3 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp3 OCA], [https://pdbe.org/3zp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zp3 RCSB], [https://www.ebi.ac.uk/pdbsum/3zp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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[[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Gamblin, S J]]
[[Category: Gamblin, S J]]
[[Category: Liu, J]]
[[Category: Liu, J]]

Current revision

INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTc

PDB ID 3zp3

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