3ztj
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.== | ==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.== | ||
| - | <StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution|resolution]] 3.41Å' scene=''> | + | <StructureSection load='3ztj' size='340' side='right'caption='[[3ztj]], [[Resolution|resolution]] 3.41Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vir|2vir]], [[1qu1|1qu1]], [[2viu|2viu]], [[1ha0|1ha0]], [[1htm|1htm]], [[5hmg|5hmg]], [[2vit|2vit]], [[2vis|2vis]], [[2hmg|2hmg]], [[1hgg|1hgg]], [[1eo8|1eo8]], [[3hmg|3hmg]], [[4hmg|4hmg]], [[1qfu|1qfu]], [[1j8h|1j8h]], [[3ztn|3ztn]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vir|2vir]], [[1qu1|1qu1]], [[2viu|2viu]], [[1ha0|1ha0]], [[1htm|1htm]], [[5hmg|5hmg]], [[2vit|2vit]], [[2vis|2vis]], [[2hmg|2hmg]], [[1hgg|1hgg]], [[1eo8|1eo8]], [[3hmg|3hmg]], [[4hmg|4hmg]], [[1qfu|1qfu]], [[1j8h|1j8h]], [[3ztn|3ztn]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [https://pdbe.org/3ztj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [https://www.ebi.ac.uk/pdbsum/3ztj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ztj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 22: | ||
==See Also== | ==See Also== | ||
*[[Antibody 3D structures|Antibody 3D structures]] | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| - | *[[Hemagglutinin|Hemagglutinin]] | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] |
| + | *[[3D structures of human antibody|3D structures of human antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 29: | Line 30: | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Collins, P J]] | [[Category: Collins, P J]] | ||
[[Category: Gamblin, S J]] | [[Category: Gamblin, S J]] | ||
Revision as of 07:17, 18 August 2022
Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.
| |||||||||||
