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3zwn

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==Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR==
==Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR==
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<StructureSection load='3zwn' size='340' side='right' caption='[[3zwn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3zwn' size='340' side='right'caption='[[3zwn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CGR:CYCLIC+GUANOSINE+DIPHOSPHATE-RIBOSE'>CGR</scene>, <scene name='pdbligand=NGD:3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]PYRIDINIUM'>NGD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGR:CYCLIC+GUANOSINE+DIPHOSPHATE-RIBOSE'>CGR</scene>, <scene name='pdbligand=NGD:3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]PYRIDINIUM'>NGD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r0s|1r0s]], [[1lbe|1lbe]], [[1r16|1r16]], [[1r12|1r12]], [[1r15|1r15]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r0s|1r0s]], [[1lbe|1lbe]], [[1r16|1r16]], [[1r12|1r12]], [[1r15|1r15]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwn OCA], [http://pdbe.org/3zwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zwn RCSB], [http://www.ebi.ac.uk/pdbsum/3zwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwn OCA], [https://pdbe.org/3zwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwn RCSB], [https://www.ebi.ac.uk/pdbsum/3zwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
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[[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Aplca]]
[[Category: Aplca]]
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[[Category: Large Structures]]
[[Category: Graeff, R]]
[[Category: Graeff, R]]
[[Category: Hao, Q]]
[[Category: Hao, Q]]

Revision as of 07:23, 18 August 2022

Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR

PDB ID 3zwn

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