3zxd

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==wild-type lysenin==
==wild-type lysenin==
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<StructureSection load='3zxd' size='340' side='right' caption='[[3zxd]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='3zxd' size='340' side='right'caption='[[3zxd]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zxd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisfe Eisfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zxd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisfe Eisfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zx7|3zx7]], [[3zxg|3zxg]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zx7|3zx7]], [[3zxg|3zxg]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxd OCA], [http://pdbe.org/3zxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zxd RCSB], [http://www.ebi.ac.uk/pdbsum/3zxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxd OCA], [https://pdbe.org/3zxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxd RCSB], [https://www.ebi.ac.uk/pdbsum/3zxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
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[[https://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3zxd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3zxd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Eisfe]]
[[Category: Eisfe]]
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[[Category: Large Structures]]
[[Category: Abrusci, P]]
[[Category: Abrusci, P]]
[[Category: Anderluh, G]]
[[Category: Anderluh, G]]

Revision as of 07:25, 18 August 2022

wild-type lysenin

PDB ID 3zxd

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