3zyj

From Proteopedia

(Difference between revisions)

Revision as of 07:28, 18 August 2022

NetrinG1 in complex with NGL1

Structural highlights

3zyj is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Related:	3zyi
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[NTNG1_HUMAN] Atypical Rett syndrome.

Function

[LRC4C_HUMAN] May promote neurite outgrowth of developing thalamic neurons.^[1] [NTNG1_HUMAN] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.^[2]

Publication Abstract from PubMed

Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3. Cognate NetrinG-NGL interactions depend on three specificity-conferring NetrinG loops, clasped tightly by matching NGL surfaces. We engineered these NGL surfaces to implant custom-made affinities for NetrinG1 and NetrinG2. In a cellular patterning assay, we demonstrate that NetrinG-binding selectivity can direct the sorting of a mixed population of NGLs into discrete cell surface subdomains. These results provide a molecular model for selectivity-based patterning in a neuronal recognition system, dysregulation of which is associated with severe neuropsychological disorders.

Structural basis for cell surface patterning through NetrinG-NGL interactions.,Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.346. PMID:21946559^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lin JC, Ho WH, Gurney A, Rosenthal A. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nat Neurosci. 2003 Dec;6(12):1270-6. Epub 2003 Nov 2. PMID:14595443 doi:http://dx.doi.org/10.1038/nn1148
↑ Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY. Structural basis for cell surface patterning through NetrinG-NGL interactions. EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.346. PMID:21946559 doi:10.1038/emboj.2011.346
↑ Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY. Structural basis for cell surface patterning through NetrinG-NGL interactions. EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.346. PMID:21946559 doi:10.1038/emboj.2011.346

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zyj"

@@ Line 1: / Line 1: @@
 ==NetrinG1 in complex with NGL1==
-<StructureSection load='3zyj' size='340' side='right' caption='[[3zyj]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
+<StructureSection load='3zyj' size='340' side='right'caption='[[3zyj]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3zyj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3zyj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYJ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zyi|3zyi]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zyi|3zyi]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyj OCA], [http://pdbe.org/3zyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zyj RCSB], [http://www.ebi.ac.uk/pdbsum/3zyj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyj ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyj OCA], [https://pdbe.org/3zyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyj RCSB], [https://www.ebi.ac.uk/pdbsum/3zyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyj ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/NTNG1_HUMAN NTNG1_HUMAN]] Atypical Rett syndrome.
+[[https://www.uniprot.org/uniprot/NTNG1_HUMAN NTNG1_HUMAN]] Atypical Rett syndrome.
 == Function ==
-[[http://www.uniprot.org/uniprot/LRC4C_HUMAN LRC4C_HUMAN]] May promote neurite outgrowth of developing thalamic neurons.<ref>PMID:14595443</ref>  [[http://www.uniprot.org/uniprot/NTNG1_HUMAN NTNG1_HUMAN]] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>
+[[https://www.uniprot.org/uniprot/LRC4C_HUMAN LRC4C_HUMAN]] May promote neurite outgrowth of developing thalamic neurons.<ref>PMID:14595443</ref>  [[https://www.uniprot.org/uniprot/NTNG1_HUMAN NTNG1_HUMAN]] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 29: / Line 29: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Aricescu, A R]]
 [[Category: Coles, C H]]

3zyj

From Proteopedia

Revision as of 07:28, 18 August 2022

NetrinG1 in complex with NGL1

Structural highlights

Disease

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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