4apu
From Proteopedia
(Difference between revisions)
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<StructureSection load='4apu' size='340' side='right'caption='[[4apu]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4apu' size='340' side='right'caption='[[4apu]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4apu]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4apu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2K:(8S,11R,13S,14S,16S,17S)-17-CYCLOPROPYLCARBONYL-16-ETHENYL-13-METHYL-11-(4-PYRIDIN-3-YLPHENYL)-2,6,7,8,11,12,14,15,16,17-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE'>A2K</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2K:(8S,11R,13S,14S,16S,17S)-17-CYCLOPROPYLCARBONYL-16-ETHENYL-13-METHYL-11-(4-PYRIDIN-3-YLPHENYL)-2,6,7,8,11,12,14,15,16,17-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE'>A2K</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a28|1a28]], [[1e3k|1e3k]], [[1sqn|1sqn]], [[1sr7|1sr7]], [[1zuc|1zuc]], [[2c7a|2c7a]], [[2w8y|2w8y]], [[3zr7|3zr7]], [[3zra|3zra]], [[3zrb|3zrb]], [[4a2j|4a2j]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a28|1a28]], [[1e3k|1e3k]], [[1sqn|1sqn]], [[1sr7|1sr7]], [[1zuc|1zuc]], [[2c7a|2c7a]], [[2w8y|2w8y]], [[3zr7|3zr7]], [[3zra|3zra]], [[3zrb|3zrb]], [[4a2j|4a2j]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apu OCA], [https://pdbe.org/4apu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apu RCSB], [https://www.ebi.ac.uk/pdbsum/4apu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 05:42, 25 August 2022
PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
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