4aq3

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<StructureSection load='4aq3' size='340' side='right'caption='[[4aq3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4aq3' size='340' side='right'caption='[[4aq3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4aq3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4aq3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=398:N,N-DIBUTYL-4-CHLORANYL-1-[2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YLCARBONYL)-4-[(7-IODANYLNAPHTHALEN-2-YL)SULFONYLCARBAMOYL]PHENYL]-5-METHYL-PYRAZOLE-3-CARBOXAMIDE'>398</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=398:N,N-DIBUTYL-4-CHLORANYL-1-[2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YLCARBONYL)-4-[(7-IODANYLNAPHTHALEN-2-YL)SULFONYLCARBAMOYL]PHENYL]-5-METHYL-PYRAZOLE-3-CARBOXAMIDE'>398</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bxl|1bxl]], [[1g5j|1g5j]], [[1g5m|1g5m]], [[1gjh|1gjh]], [[1lxl|1lxl]], [[1maz|1maz]], [[1r2d|1r2d]], [[1r2e|1r2e]], [[1r2g|1r2g]], [[1r2h|1r2h]], [[1r2i|1r2i]], [[1ysg|1ysg]], [[1ysi|1ysi]], [[1ysn|1ysn]], [[1ysw|1ysw]], [[2b48|2b48]], [[2w3l|2w3l]], [[2xa0|2xa0]], [[2yj1|2yj1]], [[4a1u|4a1u]], [[4a1w|4a1w]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bxl|1bxl]], [[1g5j|1g5j]], [[1g5m|1g5m]], [[1gjh|1gjh]], [[1lxl|1lxl]], [[1maz|1maz]], [[1r2d|1r2d]], [[1r2e|1r2e]], [[1r2g|1r2g]], [[1r2h|1r2h]], [[1r2i|1r2i]], [[1ysg|1ysg]], [[1ysi|1ysi]], [[1ysn|1ysn]], [[1ysw|1ysw]], [[2b48|2b48]], [[2w3l|2w3l]], [[2xa0|2xa0]], [[2yj1|2yj1]], [[4a1u|4a1u]], [[4a1w|4a1w]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq3 OCA], [http://pdbe.org/4aq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4aq3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq3 OCA], [https://pdbe.org/4aq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aq3 RCSB], [https://www.ebi.ac.uk/pdbsum/4aq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
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[[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
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[[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[B-cell lymphoma protein|B-cell lymphoma protein]]
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Bertrand, J A]]
[[Category: Bertrand, J A]]
[[Category: Fasolini, M]]
[[Category: Fasolini, M]]

Revision as of 05:42, 25 August 2022

HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR

PDB ID 4aq3

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