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4as7
From Proteopedia
(Difference between revisions)
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<StructureSection load='4as7' size='340' side='right'caption='[[4as7]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='4as7' size='340' side='right'caption='[[4as7]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4as7]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4as7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AS7 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LX:N-(3-AMINOPROPYL)-N-[(1R)-1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL]-4-METHYLBENZAMIDE'>6LX</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LX:N-(3-AMINOPROPYL)-N-[(1R)-1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL]-4-METHYLBENZAMIDE'>6LX</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ii6|1ii6]], [[1q0b|1q0b]], [[1x88|1x88]], [[1yrs|1yrs]], [[2fky|2fky]], [[2fl2|2fl2]], [[2fl6|2fl6]], [[2g1q|2g1q]], [[2gm1|2gm1]], [[2uyi|2uyi]], [[2uym|2uym]], [[2wog|2wog]], [[2x2r|2x2r]], [[2x7c|2x7c]], [[2x7d|2x7d]], [[2x7e|2x7e]], [[2xae|2xae]], [[4a1z|4a1z]], [[4a28|4a28]], [[4a50|4a50]], [[4a51|4a51]], [[4a5y|4a5y]], [[4ap0|4ap0]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6|1ii6]], [[1q0b|1q0b]], [[1x88|1x88]], [[1yrs|1yrs]], [[2fky|2fky]], [[2fl2|2fl2]], [[2fl6|2fl6]], [[2g1q|2g1q]], [[2gm1|2gm1]], [[2uyi|2uyi]], [[2uym|2uym]], [[2wog|2wog]], [[2x2r|2x2r]], [[2x7c|2x7c]], [[2x7d|2x7d]], [[2x7e|2x7e]], [[2xae|2xae]], [[4a1z|4a1z]], [[4a28|4a28]], [[4a50|4a50]], [[4a51|4a51]], [[4a5y|4a5y]], [[4ap0|4ap0]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4as7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4as7 OCA], [https://pdbe.org/4as7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4as7 RCSB], [https://www.ebi.ac.uk/pdbsum/4as7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4as7 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Kinesin|Kinesin]] | + | *[[Kinesin 3D Structures|Kinesin 3D Structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kozielski, F]] | [[Category: Kozielski, F]] | ||
[[Category: Talapatra, S K]] | [[Category: Talapatra, S K]] | ||
[[Category: Motor protein]] | [[Category: Motor protein]] | ||
Revision as of 05:44, 25 August 2022
Eg5 complex 1
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