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4atx

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<SX load='4atx' size='340' side='right' viewer='molstar' caption='[[4atx]], [[Resolution|resolution]] 8.20&Aring;' scene=''>
<SX load='4atx' size='340' side='right' viewer='molstar' caption='[[4atx]], [[Resolution|resolution]] 8.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4atx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4ATX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4atx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ATX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jff|1jff]], [[1sa0|1sa0]], [[1sa1|1sa1]], [[1tvk|1tvk]], [[1z2b|1z2b]], [[2wbe|2wbe]], [[2xrp|2xrp]], [[4aqv|4aqv]], [[4aqw|4aqw]], [[4atu|4atu]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jff|1jff]], [[1sa0|1sa0]], [[1sa1|1sa1]], [[1tvk|1tvk]], [[1z2b|1z2b]], [[2wbe|2wbe]], [[2xrp|2xrp]], [[4aqv|4aqv]], [[4aqw|4aqw]], [[4atu|4atu]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atx OCA], [http://pdbe.org/4atx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4atx RCSB], [http://www.ebi.ac.uk/pdbsum/4atx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4atx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atx OCA], [https://pdbe.org/4atx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4atx RCSB], [https://www.ebi.ac.uk/pdbsum/4atx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4atx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/KINH_RAT KINH_RAT]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).[UniProtKB:Q61768] [[http://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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[[https://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[https://www.uniprot.org/uniprot/KINH_RAT KINH_RAT]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).[UniProtKB:Q61768] [[https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 05:46, 25 August 2022

Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin

4atx, resolution 8.20Å

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