1g5s
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(New page: 200px<br /> <applet load="1g5s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g5s, resolution 2.61Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 14:54, 12 November 2007
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CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717
Overview
Cyclin-dependent kinases (CDKs) are regulatory proteins of the eukaryotic, cell cycle. They act after association with different cyclins, the, concentrations of which vary throughout the progression of the cell cycle., As central mediators of cell growth, CDKs are potential targets for, inhibitory molecules that would allow disruption of the cell cycle in, order to evoke an antiproliferative effect and may therefore be useful as, cancer therapeutics. We synthesized several inhibitory, 2,6,9-trisubstituted purine derivatives and solved the crystal structure, of one of these compounds, H717, in complex with human CDK2 at 2.6 A, resolution. The orientation of the C2-p-diaminocyclohexyl portion of the, inhibitor is strikingly different from those of similar moieties in other, related inhibitor complexes. The N9-cyclopentyl ring fully occupies a, space in the enzyme which is otherwise empty, while the C6-N-aminobenzyl, substituent points out of the ATP-binding site. The structure provides a, basis for the further development of more potent inhibitory drugs.
About this Structure
1G5S is a Single protein structure of sequence from Homo sapiens with I17 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717., Dreyer MK, Borcherding DR, Dumont JA, Peet NP, Tsay JT, Wright PS, Bitonti AJ, Shen J, Kim SH, J Med Chem. 2001 Feb 15;44(4):524-30. PMID:11170642
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