4b03

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<SX load='4b03' size='340' side='right' viewer='molstar' caption='[[4b03]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
<SX load='4b03' size='340' side='right' viewer='molstar' caption='[[4b03]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b03]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4B03 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b03]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B03 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4azx|4azx]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4azx|4azx]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b03 OCA], [http://pdbe.org/4b03 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b03 RCSB], [http://www.ebi.ac.uk/pdbsum/4b03 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b03 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b03 OCA], [https://pdbe.org/4b03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b03 RCSB], [https://www.ebi.ac.uk/pdbsum/4b03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b03 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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[[https://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 05:52, 25 August 2022

6A Electron cryomicroscopy structure of immature Dengue virus serotype 1

4b03, resolution 6.00Å

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OCA

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