1i16
From Proteopedia
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'''STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES''' | '''STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES''' | ||
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[[Category: Renner, C.]] | [[Category: Renner, C.]] | ||
[[Category: Zweckstetter, M.]] | [[Category: Zweckstetter, M.]] | ||
| - | [[Category: | + | [[Category: Cytokine]] |
| - | [[Category: | + | [[Category: Lymphocyte chemoattractant factor]] |
| - | [[Category: | + | [[Category: Pdz domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:08 2008'' | |
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Revision as of 16:27, 2 May 2008
STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES
Overview
The structure of a folded core of IL-16 is similar to that of intracellular protein modules called PDZ domains. IL-16 is thus the first extracellular protein found to have a PDZ-like fold. However, it does not exhibit normal peptide binding properties of PDZ domains. This is due to alterations of the structure at the 'PDZ-like binding site' of IL-16 (the GLGF cleft): the GLGF cleft of IL-16 is much smaller than those of PDZ-domains and is additionally blocked with a tryptophan side chain at its center. Our experiments indicate also that IL-16 nonspecifically aggregates in solution; but formation of a homo-tetrameric protein is not required, in contrast to previous suggestions, for its chemo-attractant activity.
About this Structure
1I16 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site., Muhlhahn P, Zweckstetter M, Georgescu J, Ciosto C, Renner C, Lanzendorfer M, Lang K, Ambrosius D, Baier M, Kurth R, Holak TA, Nat Struct Biol. 1998 Aug;5(8):682-6. PMID:9699630 Page seeded by OCA on Fri May 2 19:27:08 2008
