1i1d

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[[Image:1i1d.gif|left|200px]]
[[Image:1i1d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i1d |SIZE=350|CAPTION= <scene name='initialview01'>1i1d</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1i1d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine_6-phosphate_N-acetyltransferase Glucosamine 6-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= YFL017C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1i1d| PDB=1i1d | SCENE= }}
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|RELATEDENTRY=[[1i12|1I12]], [[1i21|1I21]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1d OCA], [http://www.ebi.ac.uk/pdbsum/1i1d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i1d RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF YEAST GNA1 BOUND TO COA AND GLNAC-6P'''
'''CRYSTAL STRUCTURE OF YEAST GNA1 BOUND TO COA AND GLNAC-6P'''
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[[Category: Mengin-Lecreulx, D.]]
[[Category: Mengin-Lecreulx, D.]]
[[Category: Peneff, C.]]
[[Category: Peneff, C.]]
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[[Category: alpha/beta]]
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[[Category: Alpha/beta]]
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[[Category: domain swapping]]
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[[Category: Domain swapping]]
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[[Category: gnat conserved core]]
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[[Category: Gnat conserved core]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:15 2008''
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Revision as of 16:27, 2 May 2008

Image:1i1d.gif

Template:STRUCTURE 1i1d

CRYSTAL STRUCTURE OF YEAST GNA1 BOUND TO COA AND GLNAC-6P


Overview

The yeast enzymes involved in UDP-GlcNAc biosynthesis are potential targets for antifungal agents. GNA1, a novel member of the Gcn5-related N-acetyltransferase (GNAT) superfamily, participates in UDP-GlcNAc biosynthesis by catalyzing the formation of GlcNAc6P from AcCoA and GlcN6P. We have solved three crystal structures corresponding to the apo Saccharomyces cerevisiae GNA1, the GNA1-AcCoA, and the GNA1-CoA-GlcNAc6P complexes and have refined them to 2.4, 1.3, and 1.8 A resolution, respectively. These structures not only reveal a stable, beta-intertwined, dimeric assembly with the GlcNAc6P binding site located at the dimer interface but also shed light on the catalytic machinery of GNA1 at an atomic level. Hence, they broaden our understanding of structural features required for GNAT activity, provide structural details for related aminoglycoside N-acetyltransferases, and highlight the adaptability of the GNAT superfamily members to acquire various specificities.

About this Structure

1I1D is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase., Peneff C, Mengin-Lecreulx D, Bourne Y, J Biol Chem. 2001 May 11;276(19):16328-34. Epub 2001 Feb 9. PMID:11278591 Page seeded by OCA on Fri May 2 19:27:38 2008

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