4b89

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<StructureSection load='4b89' size='340' side='right'caption='[[4b89]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4b89' size='340' side='right'caption='[[4b89]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B89 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B89 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b8a|4b8a]], [[4b8b|4b8b]], [[4b8c|4b8c]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b8a|4b8a]], [[4b8b|4b8b]], [[4b8c|4b8c]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b89 OCA], [http://pdbe.org/4b89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b89 RCSB], [http://www.ebi.ac.uk/pdbsum/4b89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b89 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b89 OCA], [https://pdbe.org/4b89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b89 RCSB], [https://www.ebi.ac.uk/pdbsum/4b89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b89 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NOT1_YEAST NOT1_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref>
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[[https://www.uniprot.org/uniprot/NOT1_YEAST NOT1_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 07:03, 31 August 2022

MIF4G domain of the yeast Not1

PDB ID 4b89

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